Non-GMO Precision Gene Editing? Cibus Is Hoping To Do Just That

Cibus, a leader in non-transgenic breeding and precision gene editing, announced today the publication of the article “Oligonucleotide-directed Mutagenesis for Precision Gene Editing” in Plant Biotechnology Journal, a journal published by Wiley-Blackwell in association with the Society for Experimental Biology (SEB) and the Association of Applied Biologists (AAB). The paper’s authors include Noel J. Sauer, Jerry Mozoruk, Ryan B. Miller, Zachary J. Warburg, Keith A. Walker, Peter R. Beetham, Christian R. Schöpke and Greg F. W. Gocal.

As part of a special focus on gene editing, Cibus contributed a review on the application of oligonucleotide-directed mutagenesis (ODM) as a precision genome editing technology. The paper emphasizes using oligonucleotides to make targeted edits in plasmid, episomal and chromosomal DNA of bacterial, fungal, mammalian and plant systems. ODM is one of the many tools of Cibus’ Rapid Trait Development System (RTDS) technology, which offers a rapid, precise and non-transgenic breeding alternative for trait improvement in agriculture to address the urgent need to accelerate the development of these traits in plants in order to increase global agricultural productivity.

“As a pioneer in plant trait development with years of research in this space, Cibus’ team is uniquely positioned to contribute to the discussion on precision gene editing,” remarked Greg Gocal, Senior Vice President, Research and Development. “It is an honor to have this article published in Plant Biotechnology Journal, and a wonderful opportunity to communicate the benefits of Cibus’ proprietary RTDS technology. As an agricultural company with innovative, cutting-edge technology Cibus will continue to help lead these conversations.”

RTDS covers many important technological breakthroughs developed by Cibus over the last decade in several areas including key aspects of cell biology, precision gene editing, advanced molecular screening, advanced breeding, and crop development technologies. The system produces non-transgenic, site specific mutations targeted using chemically synthesized gene repair oligonucleotides (GRONs) in half the time of other breeding techniques. RTDS harnesses the cell’s natural DNA-repair systems to correct and change specific targeted bases within the genome of a cell.

The article “Oligonucleotide-directed Mutagenesis for Precision Gene Editing” can be found here.

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